The latest version of SeizureScan has the ability to operate in one of two modes: Short‐Term/Acute Mode or Long‐term/Chronic Mode. In the Short‐Term/Acute mode, typical of a PTZ test, the animal is monitored for a short duration, say, 30 min or so. During this time, the progress of seizure activity from normal behavior (P0) to Behavior Arrest (P1), to Twitches (P2), to Forelimb Clonus (P3), to Generalized Clonic Seizures (P4), to Jumpy/Bouncy Seizures (P5), to Tonic Extension (P6) are analyzed. In the Long‐Term Chronic mode, where seizures can be analyzed over extended periods of time, SeizureScan detects seizures of 3 types that are classified using the Racine scale – P3, P4 and P5 class seizures, with P3 seizures being relatively mild seizures to P5 seizures being the most violent.

Validation studies with mice in the Short‐Term mode have shown high correlation with human scoring. Automation of this test now makes unconstrained high‐throughput screening possible for the first time! Validation studies in rats under Chronic Mode have shown that both sensitivity and specificity have been optimized to approximately 80% levels simultaneously. Sensitivity levels can be increased by adjusting a few detection parameters in such a manner that false negatives are substantially minimized, while tolerating a slight increase in false positives, which can easily be filtered out using built‐in manual‐review based filtering tools.

SeizureScan can also be integrated with an EEG system so that SeizureScan displays the real‐time synchronized EEG data on the SeizureScan interface. The EEG data scrolls automatically as the video advances during analysis. Clicking on a point in EEG will immediately locate corresponding video frame, vice versa. Since the video signals and the EEG signals are correlated in time, cues from one can be applied to the other to achieve synergy between the two channels of data.

This will be a powerful tool for scientists as the ability to screen animals for seizures automatically can be a tremendous resource. SeizureScan can be combined with HomeCageScan into a single system thereby allowing detection of not only seizure activity, but all the other behaviors that HomeCageScan can detect. This allows the user to determine what the animal was doing when it is not having a seizure.

Moreover, with multiple cameras hooked up to SeizureScan systems, the number of cages analyzed simultaneously can be increased further.

Many advanced features are incorporated, including supporting full color analysis, automatic adapting of changing environment, automated handling of day/night switches, variable speed playback of specific video segment for specific detected behavior, etc. Complete Turn‐key systems including all necessary Hardware and Software are available. Custom design of your environment to facilitate analysis, including lighting condition setup, IR/red light setup, cage enclosures, video integration, and video‐feed to computer is also available.

This product is protected by US Patent(s) # 6,678,413; 7,068,842; 7,209,588; 7,643,655