Phenotyping after a gene insertion/extraction is essential prior to any additional assessment of the animal’s cognition; unfortunately testing stress could cause epigenetic changes within the animal model. Measuring an animal’s most basic behavioral response is more easily done in the laboratory animal’s most natural setting, unconstrained, making the home cage the most ideal testing arena for phenotypic changes due to treatment effects of gene insertion/extraction. HomeCageScan was developed to give researchers the capability to observer the animal’s home cage behaviors around the clock, without inducing additional confounds, in any animal study.