Introducing the first of its kind IVC-Rack based 24-hr Home Cage Behavior Recognition System.

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Automation of multi-species behavior

Technology for automated behavioral analysis, from humans to drosophilae.

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Revolutionary Software

Over 30 software programs to assist researchers with the analysis of the complex and naturalistic behaviors of their subjects.

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Our products optimize the environmental conditions for video analysis, ensuring researchers obtain accurate results.

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Automated Animal Behavior Analysis – Software, Hardware, and Services

Clever Sys is a leading bioinformatics company specializing in software and hardware for automated animal behavior analysis. Our video-based Behavior Recognition technology provides comprehensive tools for pre-clinical research including all necessary hardware for various behavior analysis paradigms, video and data acquisition and automated behavior analysis software. Clever Sys brings behavioral testing into the twenty-first century, enhancing video tracking with our patented next generation Behavior Recognition technology!

Explore our full suite of Software, Hardware, and service offerings. Or, you can also start by exploring the Application Areas that you may be interested in.

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New Product Releases

Frictionless TreadScan Automated Systems (Beta)

Date: 2017-07-23 18:53:22

Frictionless TreadScan is the latest addition to our product line for motor function, and it is also the newest for measuring gait and neuro-function simultaneously on a head-fixed animal. The frictionless TreadScan is a fully automated test for detecting coordinated neuro-activities while the animal walking is on a frictionless treadmill with its head fixed. The system consists of a special treadmill that has a transparent belt like our ExerGait treadmill in TreadScan system, however, the belt has almost no friction and the animals can walk on it to propel the belt backward. The system has a head fixing device that can keep its head fixed while actively walking so that neuron firing, optogenetics, fiber photometry etc. can be performed on the active animal. A mirror is installed underneath the transparent frictionless belt and sees all the foot prints of animal walking on the belt. A high speed camera capable of capturing video at 100 frames per second or greater is installed opposite to the mirror and records the video using the BCamCapture software. Liquid reward delivery is achieved by installing a pump that delivers liquid to the animal for drinking. Control and measurement of delivery is implemented. When neuron firing, optogenetics, fiber photometry etc. are executed, those generated signals that are read and recorded in-sync with the videos. Enhanced TreadScan software, as used in TreadScan system, is used to analyze the recorded video and signal code. It will generate complete set of gait data, as well as the signal code. TreadScan outputs the detailed results of these parameters from analysis into Microsoft Excel and gives statistical results to meet research requirements. Advanced functionalities such as batch mode analysis, group export, direct analysis of AVI captured files, and post‐hoc conversion to compressed MPEG videos to save disk‐space are available. A sample screenshot of the TreadScan software is shown to the right. The stride data is shown on the right for each foot individually. The results are updated as the analysis takes place.

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Date: 2017-07-14 18:53:58

LadderScan is our latest addition to our product lines for motor function, and the new one for motor learning. Like our comprehensive full body motor function measurement product HomecageScan, limb specific motor function of Gait Analysis Suite of products, and simple open field test for basic motor function TopScan LITE, LadderScan provides another measurements of visually-guided motor function, and it also provides motor learning function that is usually hard to measure without expensive equipment and surgery! The LadderScan is a fully automated test for detecting motor performance, associative motor learning deficits and cognitive phenotypes in mouse models. The LadderScan consists of a horizontal ladder in between two shelter boxes. Each shelter boxes are equipped with automatic doors, tones, fans and shockers. All these stimuli are used as cues for departure. They control the speed of the mice and to prevent them from leaving the shelter box at the opposite side and crossing the ladder at unwanted moments. These provide user with the capability of various powerful and flexible experiment configurations. Two automatic doors are installed at both ends of the ladder which controls animal’s walking in and out. Two small enclosures are used at both ends to make animal confortable to walk to the end. which are equipped with a bright white LED spotlight in the roof and two pressurized air outlets High pitch tone and Both, light and air stimuli are used as cues for departure. In addition, one of the air outlets is used to control the speed of the mice and to prevent them from leaving the shelter box at the opposite side and crossing the ladder at unwanted moments (which we call ‘escape’).. The ladder has 2 × 37 rungs for the left and right side. All rungs are touch sensitive sensors,, which are continuously monitored and which can be used to register and analyze the walking pattern of the mouse instantaneously. Moreover, based upon the prediction of the walking pattern, the rungs can be moved up or down by a novel device. The computer system (runs the real-time system recording sensor data, adjusts air pressure, predicts future touches, calculates interventions, repositions slides and stores data, operates in a fixed cycle of 2. The LadderScan (see figure ) is a horizontal ladder on which mice can perform several visually-guided stepping paradigms. The mouse traverses this ladder while the touch sensitive rungs. This allows the system to measure step time and length, missteps, back steps, and jumps, while cerebellar functioning is tested in a challenge that involves a barrier raising during the run. Classical conditioning could be performed on a horizontal ladder by presenting a tone just prior to raising or lowering a ladder rung in the path of the moving animal. Furthermore, evidence suggests that this form of associative motor learning would likely be cerebellum-dependent: unexpected ladder rung perturbation during visually guided stepping caused modulation of activity in the cat cerebellar cortex and deep cerebellar nuclei. LadderScan’s Features: • average steptimes for every unperturbed session • the average duration of the step that immediately followed the onset of the US • the average duration of the step that immediately preceded the onset of the US • Short step: step from one high rung to the next high rung • Long step: skipping one high rung • Jump: skipping two high rungs • Misstep: a step forward, but the paw is placed on a low rung • Back step: a step back from one high rung to the previous high rung • Pre-perturbation step: the step before perturbation • Post-perturbation step: the step during (over) the perturbation Unique Capabilities: • Light Cue • Tone Cue • Electrical Shocker Cue • Air Puff Cue Applications: • Motor Function Measurement • Motor Learning Function Measurement • Software Interface • Automatic Doors

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Date: 2017-07-12 18:53:55

KinemaScan is the newest addition to our NeurodegenScan Suite and provides a multi‐dimensional ventral and side‐view kinematic gait analysis of animals. Kinematic Gait analysis allows highly sensitive, noninvasive detection and evaluation of many pathophysiological conditions, such as those occurring in Spinal Cord Injury, Parkinson’s disease, Alzheimer’s disease, ALS, arthritis, pain, neuromuscular and skeletal muscle diseases. kinema KinemaScan is a multi‐dimensional analysis system that takes video of animal (mouse/rat/guinea pig) running on a transparent belt treadmill as input from 2 different views: Ventral view for traditional TreadScan based video analysis and Side view for joint‐motion Kinematic Analysis. The ventral and side‐view videos of the animal are obtained using a pair of high‐speed digital cameras and each video capture can be 20 seconds (or even more when used with specialized fast hard drive architecture) giving a multitude of stride samples in just one trial. The ventral view video essentially captures the foot prints of the animal as they walk/run on the treadmill. The side view video captures motion of the joints using reflectors or color markers affixed to the landmark points on the animals’ limbs. Both views are synchronized during video capture. KinemaScan can reliably analyze these multi‐dimensional synchronized video, and determine various characteristic parameters that are related to the pathophysiological conditions. These parameters include all traditional ventral view gait parameters provided by TreadScan including stance time, swing time, total stride time, stride length, foot contact area size, foot pressure (measured using color intensity levels), body‐foot spacing distance (distances between body and feet), foot spacing distances (distance between various feet), running speed, stride frequencies, foot coupling or coordination measures (in‐phase or out‐of‐phase gait patterns of feet), and Foot Print Analysis related measures such as foot print placement rotation angle with body and toe spread factors (splay) among many others. However, KinemaScan also provides Side View kinematic Joint movement data using markers placed on joints that includes Joint Trajectories or Tracks over time and their patterns, Joint angles between surrounding joints and there variation over time among many others. KinemaScan outputs the detailed results of these parameters from analysis into Microsoft Excel files and gives statistical results to meet requirements in the research. Advanced functionalities such as batch mode analysis, group export, direct analysis of AVI captured files, and post‐hoc conversion to compressed MPEG videos to save disk‐space are available. A sample screenshot of the TreadScan software is shown below. The stride data is shown on the right for each foot individually. The results are updated as the analysis takes place. Capabilities •Complete GLP‐compliant System •Analyzes video at speeds of up to 175 fps and video resolution up to 656x480 in each view •Detects feet in animals with almost similar coat color like Agouti and White mice! • Works with rodents of all colors/sizes • Stores video in MPEG with high‐compression for optimal use of disk space • Provides a Comprehensive set of gait measures • Export Stance Graph (a timing diagram of the foot stances and the foot contact size information) and the Ink‐Pad image showing the foot placement positions • Ability to automatically flag outliers for further review and discard unusable portions of video

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RFID‐Assisted SocialScan

Date: 2017-07-12 18:53:32

Radio Frequency Identification (RFID) systems use radio frequency to identify, locate and track people, assets and animals. RFID‐assist has been successfully added to Clever Sys Behavior Recognition products to enhance our lab animal behavior analysis system functionality, performance, and reliability. RFID‐ Assisted SocialScan is first such application. SocialScan is a member of our SocialScan Suite that quantitatively and qualitatively measures social behaviors of two or more animals that are enclosed in a single arena, whether it is a simple home cage or a complex arena. SocialScan captures and tracks these animals (rodents) in an arena, and automatically determines various social interactions among them. Using implanted RFID tags in the animal and a platform consisting of an array of RFID detectors placed under the device (cage or arena), the system utilizes radio frequency to localize the tags implanted into animals, thereby constantly monitoring the position of each animal. Simultaneously, video analysis tracks the entire body, position, and many other features of each animal. Combining information obtained from both of these channels, the SocialScan system is able to track the animals extremely reliably over extended periods of time! Pure video‐based analysis that requires distinguishable marks on the animals is unable to scale beyond 2 or 3 animals. However, with the advent of RFID‐assisted video analysis, we are able to track many more animals with accurate IDs. This is a landmark innovation that Clever Sys is proud to offer going forward. SocialScan has several unique and important features in analyzing social behaviors among animals. First, the system can differentiate multiple animals without artificially coloring (labeling) them, as long as they have some perceivable difference in terms of natural color or size. The system will automatically determine who is who, even after two animals get together and then separate. The system can automatically differentiate two animals even when they are in contact, an extremely important feature to have. The RFID‐assist further enhances this capability. If visible marking is insufficient or impractical, or if you simply need more accuracy, you have the option now of using RFID‐Assisted SocialScan to successfully resolve any issues with tracking IDs. SocialScan system can automatically determine if animals are in contact with each other, if any two animals are approaching each other, leaving (avoiding) each other, one is following the other, or simply, or if one is sniffing at the other’s head, mid‐ body or genital area. More advanced events have been recently added, including Staring, Active Contact or Passive Contact, specific body‐part to body‐part contact, and Mount. Dynamically updated Social Distance between pairs of animals (e.g., how many times does Animal A get to within 10 cm of Animal B) are also available. Second, the system can automatically identify the head and tail of each of animal; therefore there is no need to artificially color their head and tail parts. The system will determine the social interactions of approach, avoidance, sniffing, and contact based on the automatically detected heads and tails of animals, and their relative spatial positions and movements. Third, the techniques for automation of the categorization and quantification of social interactions between animals have been applied to achieve high throughput screening. System architecture has been optimized for high throughput screening . The Realtime Option is necessary to perform realtime analysis where the live video feed into the computer is compressed, encoded, saved to the hard drive while simultaneously full analysis of the video is performed. Contact us to learn more or to schedule a demo of this latest innovation from Clever Sys.

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Optogenetics and Fiber Photometry

Date: 2017-07-12 18:53:18

Optogenetics and fiber photometry are neuro-modulation technologies in neuroscience that utilizes a combination of light and genetics to control and monitor neurons in vivo. Clever Sys Inc., programs can be synchronized with optogenetic actuators and sensors and fiber photometry devices allowing for acquisition of behavioral data during experiments. Any of our software programs can be integrated with optogenetics/fiber photometry by using TTL and a specially developed software interface. This brings research into a new realm with the possibility of simultaneous control of biochemical events of living freely behaving animals and the collection of this data in both high-throughput and real-time. Many of our hardware devices such as our treadmill, runway, operant chambers are fully equipped to accommodate the need for fiber optic tethers so animal movement during behavioral testing will not be inhibited. Ideal for experiments mapping function of the amygdala such as fear conditioning, studies for targeting pharmacotherapies and addiction via nucleus accumbens, expression of pyramidal neurons in PFC and genetic components of social behavior and drug efficacy in neuropsychiatric disorders etc. Whatever your experimental needs Clever Sys, will work with you to provide the best system for your data collection needs to provide high quality reliable results and the best behavioral analysis software available. Although any of our programs can be integrated with optogenetic/fiber photometry systems optimal candidates include: • SeizureScan • HomecageScan • GroupHouseScan • FreezeScan • ChamberScan • GaitScan • TreadScan • RunwayScan • TopScan • SocialScan

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Date: 2017-07-12 18:53:15

Clever Sys offers a highly versatile and customizable range of software options for the analysis of Zebrafish (Danio rerio) behavior in both adults and larvae. AquaScan provides single/Multiple organisms tracking along with TTL control for stimulus delivery. Behavior can be analyzed for single organism, multiple fish, or for groups, like fish activities, animal traces, shoaling statistics, group behavior statistics, zone-revelant behaviors, etc . It can be used for traditional and specialized paradigms such as: Open field, CPP, T-maze, Y-Maze, Fear Conditioning, Fear Response (predatory), Seizure, Locomotion, Photoaxis tests, Optokinetic tests, Shoaling and Social Behavior Test. AquaScan Features Video Acquisition, Fish Tracking and Behavior Recognition. Experiment starting/stopping time control Light/Shock Stimulus Control Contextual Stimuli Control Real-time and offline data acquisition Single/multiple fish, multiple group acquisition simultaneously. Support multiple channel acquisitions Data analysis with different protocols. Original data, behavior data export and visualization (Excel or Open Office) Extensive experiment database management Batch analysis White, IR, or Red light capability AquaScan Behavior (x,y) coordinats and trace for each fish Times, duration, moving distance and average speed for each fish in each zone Immobile, low activity, normal activity and intensive activity Sharp turning Sniffing specific zones, like cage bottom Shoaling: pair-wise fish inter-distance Social contact, following, chasing, etc. Sociability: bouts of several fish swimming closely in a similar direction. Drop test: statistics of distance and speed for all fish Statistics of group behaviors: number of active animals, average moving distance, etc. cardiovascular data recording, analysis and export Up to 92 arenas for each camera, multiple camera multiplexing CSI-CPP-ZF The CSI-CPP-ZF Apparatus has been specially designed for Zebrafish tests of conditioned place preference or self administration studies. The device has 3 lanes with removable doors some of which have holes designed to close off or allow free passage of animals in between sections of the chamber. The CPP chamber is made of clear acrylic to optimize video observation and to allow ambient backlighting for superior tracking. ZebraEnv  Our ZebraEnv is a newly designed Zebrafish Larvae analysis chamber system that includes state-of-the-art features for providing a finely controlled environment for larvae behavior analysis. It contains a high-speed digital camera placed at the top viewing downward at a stage that is back-lit by a dimmable LED light panel whose intensity is capable of being adjusted by the software. The stage comprises a water bath with the ability to insert well-plates of standard size. Up to 96-count well plates can be accommodated. The salient feature of the stage is a unique vibration-free temperature control system. It uses a vibration free heating element instead of commonly used water-pump based water flow bath that can cause vibration effects on the wells. Our design does not have a water flow that cause vibrations in the wells. This is very critical for zebrafish larvae. The camera is placed strategically such that it produces distortion free imaging of the outermost wells in a dense well plate StereoScan Comprehensive Top and Side view analysis! Detailed information on Zebrafish behavior Events detected include: zone visits, crossovers, speed, motion, dist to points, dist to zones, orient to points, circling, motion, in-place motion, shape, stretch attend, head dip, turn, disappear, % body in zone, rear up, come down, hang, walk, jump, groom, eat, drink, sleep, etc. Continuous recording available for long term analysis High-Throughput Option for up to 2 cages simultaneously.

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